O104

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O104

Sigma

 

Omeprazole

solid

Synonym:Antra, Losec, 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
CAS Number:73590-58-6
Linear Formula:C17H19N3O3S
Molecular Weight:345.42
MDL number:MFCD00083192
PubChem Substance ID:24897870

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Description

Biochem/physiol ActionsBinds covalently to proton pump; inhibits gastric secretion.
CautionHygroscopic, photosensitive

Properties

formsolid
color white
solubilityH2O: 0.5 mg/mL
 DMSO: 19 mg/mL
 ethanol: 4.5 mg/mL
Gene Informationhuman ... ABCB1(5243), CYP1A2(1544)
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36
WGK Germany2
RTECSDD9087000

References

referenceMorii, M., et al., Different biochemical modes of action of two irreversible H+K (+)-ATPase inhibitors omeprazole and E3810. J. Biol. Chem. 268, 21553, (1993) Abstract
 Ritter, M. et al., Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume intracellular pH and migration of human polymorphonuclear leucocytes. Br. J. Pharmacol. 124, 627-638, (1998) Abstract